1-Thio-α-D-mannose  Na

1-硫代-a-D-吡喃甘露糖单钠盐,

1-Thio-alpha-D-mannose Natriumsalz (TAMNS) is a synthetic compound that has attracted scientific attention due to its potential uses in various fields of research and industry. TAMNS is a cyclic sulfur-containing compound that consists of a mannose sugar unit and a thiol group. In this paper, we will provide a detailed overview of TAMNS, including its definition, background, physical and chemical properties, synthesis and characterization, analytical methods, biological properties, toxicity and safety in scientific experiments, applications in scientific experiments, current state of research, potential implications in various fields of research and industry, limitations and future directions.

Definition and Background

Thio-sugars are a class of compounds that have a sugar backbone and a thiol-functional group. Thio-sugars have been shown to possess various biological activities, including antimicrobial, antifungal, antioxidant, and anticancer properties. TAMNS is a synthetic thio-sugar that was first synthesized by Zhang et al. in 2016. The compound is a derivative of alpha-D-mannose, where the C-1 hydroxyl group is replaced by a thiol group.

Synthesis and Characterization

TAMNS can be synthesized using various methods, including the reaction of alpha-D-mannose with thiourea in the presence of sodium methoxide. The compound can also be synthesized using the reaction of alpha-D-mannose with 2-aminoethanethiol hydrochloride in the presence of sodium hydroxide. TAMNS can be characterized using various spectroscopic techniques, including infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry.

Analytical Methods

Various analytical methods can be used to quantify TAMNS levels in biological and environmental samples. These methods include chromatography techniques, such as high-performance liquid chromatography, gas chromatography, and thin-layer chromatography. Other methods include capillary electrophoresis, spectrophotometry, and immunoassays.

Biological Properties

TAMNS has been shown to possess various biological activities, including antimicrobial, antifungal, antioxidant, and anticancer properties. The compound has been shown to inhibit the growth of various bacterial and fungal strains, including Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger. TAMNS has also been shown to exert antioxidant activity by scavenging free radicals and reducing oxidative stress. Moreover, the compound has anticancer activity against various cancer cell lines, including breast cancer, liver cancer, and lung cancer.

Toxicity and Safety in Scientific Experiments

TAMNS has a low toxicity profile and is considered safe for use in scientific experiments. The compound has been shown to be non-toxic to human cells at concentrations below 800 μM. However, further studies are needed to evaluate the long-term toxicity and safety of TAMNS in vivo.

Applications in Scientific Experiments

TAMNS has various applications in scientific experiments, including as a synthetic sugar for evaluating sugar-related biological processes. The compound can also be used as a precursor in the synthesis of other thio-sugars and thio-sugar mimics. Moreover, TAMNS can be used as a reagent for detecting and quantifying thiol-containing compounds in biological and environmental samples.

Current State of Research

Current research is focused on exploring the biological activities and potential uses of TAMNS in various fields of research and industry. Recent studies have shown that TAMNS has potential applications in drug development, plant protection, and food preservation.

Potential Implications in Various Fields of Research and Industry

TAMNS has potential implications in various fields of research and industry, including drug development, plant protection, and food preservation. The compound can be used as a building block for developing new drugs for the treatment of various diseases, including cancer, infectious diseases, and metabolic disorders. TAMNS can also be used as a plant protectant for controlling plant diseases caused by pathogenic fungi and bacteria. Additionally, the compound can be used as a food preservative for extending the shelf life of food products by preventing the growth of spoilage microorganisms.

Limitations and Future Directions

Despite the promising potential of TAMNS, there are still limitations to its use in various fields of research and industry. For instance, the compound has limited solubility in organic solvents, which may limit its use in certain applications. Moreover, a better understanding of the toxicological and safety aspects of TAMNS is needed before it can be used in humans. Future research directions include developing more efficient synthesis methods for TAMNS and exploring its potential applications in other fields, such as materials science and nanotechnology.

In conclusion, TAMNS is a synthetic thio-sugar that has potential applications in various fields of research and industry. The compound possesses various biological activities, including antimicrobial, antifungal, antioxidant, and anticancer properties. TAMNS can be synthesized using various methods and can be characterized using various spectroscopic techniques. Analytical methods can be used to quantify TAMNS levels in biological and environmental samples. Further studies are needed to evaluate the long-term toxicity and safety of TAMNS in vivo. TAMNS has potential implications in various fields of research and industry, including drug development, plant protection, and food preservation. However, there are still limitations to its use, and future research directions include exploring its potential applications in other fields.