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  • 176161-24-3 , 苯并咪唑核苷 , Maribavir, CAS:176161-24-3
176161-24-3 , 苯并咪唑核苷 , Maribavir, CAS:176161-24-3

176161-24-3 , 苯并咪唑核苷 , Maribavir, CAS:176161-24-3

176161-24-3 , 苯并咪唑核苷,
Maribavir,
CAS:176161-24-3
C15H19Cl2N3O4 / 376.235

苯并咪唑核苷 , Maribavir

Potent antiviral against HCMV and Epstein-Barr virus (EBV)

Maribavir is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of viral UL97 kinase, which is involved in viral nuclear maturation events, such as viral DNA assembly and movement of viral capsids from the nucleus of infected cells. Maribavir has activity against strains of CMV that are resistant to standard anti-CMV agents.

CAS Number176161-24-3
Product NameMaribavir
IUPAC Name(2S,3S,4R,5S)-2-[5,6-dichloro-2-(propan-2-ylamino)benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Molecular FormulaC15H19Cl2N3O4
Molecular Weight376.235 g/mol
InChIInChI=1S/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/m0/s1
InChI KeyKJFBVJALEQWJBS-XUXIUFHCSA-N
SMILESCC(C)NC1=NC2=CC(=C(C=C2N1C3C(C(C(O3)CO)O)O)Cl)Cl
SolubilitySoluble in DMSO
Synonyms1263W94, 5,6-dichloro-2-isopropylamino-1-b-L-ribofuranosyl-1H-benzimidazole, benzimidavir, BW 1263W94, BW-1263W94, GW 1263, GW 257406X, GW-1263, GW-257406X, GW257406X, maribavir
Canonical SMILESCC(C)NC1=NC2=CC(=C(C=C2N1C3C(C(C(O3)CO)O)O)Cl)Cl
Isomeric SMILESCC(C)NC1=NC2=CC(=C(C=C2N1[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O)Cl)Cl


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