20972-29-6 , Galacto-N-biose,Gal-b1,3-GalNAc;
2-Acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-D-galactopyranose; Thomsen-Fridenreich antigen;
b1-3 Galactosyl-N-acetyl galactosamine; T antigen
C14H25NO11 / 383.35
MFCD00063995
2-Acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-D-galactopyranose;
b1-3 Galactosyl-N-acetyl galactosamine; T antigen
2-Acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-D-galactopyranose (also known as galacto-N-biose, GNB and T antigen) is a β 1-3’ linked disaccharide which is found in the gastrointestinal tract as a core component of mucin. GNB has been shown to have potential to protect against glutamate excitotoxicity, a process in which nerve cells can be damaged or destroyed. GNB, along with lactose-N-biose, are found in human milk but are not metabolised by gut enzymes and are instead broken down to a digestible form by bifidobacteria found in the intestinal systems of infants in a symbiotic process.
Beta-D-Galp-(1->3)-D-GalpNAc is an amino disaccharide consisting of D-galactopyranose at the non-reducing end joined by a (1->3) glycosidic linkage to N-acetyl-D-galactopyranosamine. It has a role as an epitope. It is a D-Galp-(1->3)-D-GalpNAc, a galactosamine oligosaccharide and an amino disaccharide.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
CAS Number | 20972-29-6 |
Product Name | beta-D-Galp-(1->3)-D-GalpNAc |
IUPAC Name | N-[(3R,4R,5R,6R)-2,5-dihydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide |
Molecular Formula | C14H25NO11 |
Molecular Weight | 383.35 g/mol |
InChI | InChI=1S/C14H25NO11/c1-4(18)15-7-12(9(20)6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8+,9+,10+,11-,12-,13?,14+/m1/s1 |
InChI Key | HMQPEDMEOBLSQB-UITYFYQISA-N |
SMILES | CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)CO)O)O)O |
Synonyms | Antigen, Large T, Antigen, Small T, Antigen, T, Antigens, Neoplasm, Viral, Antigens, T, Antigens, Viral Neoplasm, Antigens, Viral T, Antigens, Viral Tumor, Antigens, Viral, Tumor, Antigens, Virus Transforming, Large T Antigen, Large T-Antigen, Neoplasm Antigens, Viral, Small T Antigen, Small T-Antigen, T Antigen, T Antigen, Large, T Antigen, Small, T Antigens, T Antigens, Viral, T-Antigen, T-Antigen, Large, T-Antigen, Small, Transforming Antigens, Virus, Tumor Antigens, Viral, Viral Neoplasm Antigens, Viral T Antigens, Viral Tumor Antigens, Virus Transforming Antigens |
Canonical SMILES | CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)CO)O)O)O |
Isomeric SMILES | CC(=O)N[C@@H]1[C@H]([C@H]([C@H](OC1O)CO)O)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O |
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