253328-56-2, 1,2-O-Isopropylidene-α-D-glucofuranose,
单丙酮葡萄糖,
CAS:253328-56-2
C9H16O6 / 220.22
MFCD00063244
单丙酮葡萄糖,
1,2-o-Isopropylidene-α-D-glucofuranose is a potent inhibitor of xylan, which is essential for the growth and development of cancer cells. This compound has been shown to inhibit the activity of several kinases involved in cancer cell proliferation, including protein kinase C and acetylcholine kinase. 1,2-o-Isopropylidene-α-D-glucofuranose exhibits anticancer properties and induces apoptosis in human cancer cells. It is an analog of aprepitant, a drug used to prevent chemotherapy-induced nausea and vomiting in cancer patients. This compound may have potential as a therapeutic agent for the treatment of various types of tumors.
CAS Number | 253328-56-2 |
Product Name | 1,2-O-Isopropylidene-alpha-D-glucofuranose |
IUPAC Name | 1-(6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol |
Molecular Formula | C₉H₁₆O₆ |
Molecular Weight | 220.22 |
InChI | InChI=1S/C9H16O6/c1-9(2)14-7-5(12)6(4(11)3-10)13-8(7)15-9/h4-8,10-12H,3H2,1-2H3 |
SMILES | CC1(OC2C(C(OC2O1)C(CO)O)O)C |
Synonyms | (5ξ)-1,2-O-(1-Methylethylidene)-α-D-xylo-hexofuranose; |
CAS No: 18549-40-1,253328-56-2 Synonyms: Acetone-D-glucoseMonoacetone glucose MAG MDL No: MFCD00063244 Chemical Formula: C9H16O6 Molecular Weight: 220.22 |
COA:
Product name 1,2-O-Isopropylidene-α-D-glucofuranose
CAS: 18549-40-1,253328-56-2 M.F.: C9H16O6 M.W.: 220.22
Quantity:100g from1.86 kg Batch No: 20100104
Items | Standards | Results |
Appearance | White crystal powder | Complies |
Solubility | Soluble in water, insoluble ether | Complies |
Identification | IR and TLC | Complies |
Melting point | 150°C - 160 °C | 156℃ -158 ℃ |
Optical Activity [α]20/D (C = 1, water) | −11° ~ −13° | -12.3° |
Water | Max.0.5% | 0.2% |
Residue on ignition | Max. 1% | 0.1% |
Heavy metal | Max. 20ppm | Complies |
TLC* | Should be one spot | One spot |
Assay | Min. 98% | 99.4% |
*The stationary phase is sillica gel, the mobile phase is EtOAc and is charcoalled with 15% H2SO4-EtOH.
References:
1. Gramera RE, Park A, Whistler RL, J. Org. Chem. 1963, Vol28, p3230
2. Borsuk K, Frelek J, ?ysek R, Urba?czyk Z, et al., Chirality 2001, Vol13, Issue 9, p533-540
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