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  • 253328-56-2, 单丙酮葡萄糖, 1,2-O-Isopropylidene-α-D-glucofuranose,   CAS: 253328-56-2
  • 253328-56-2, 单丙酮葡萄糖, 1,2-O-Isopropylidene-α-D-glucofuranose,   CAS: 253328-56-2
253328-56-2, 单丙酮葡萄糖, 1,2-O-Isopropylidene-α-D-glucofuranose,   CAS: 253328-56-2253328-56-2, 单丙酮葡萄糖, 1,2-O-Isopropylidene-α-D-glucofuranose,   CAS: 253328-56-2

253328-56-2, 单丙酮葡萄糖, 1,2-O-Isopropylidene-α-D-glucofuranose, CAS: 253328-56-2

253328-56-2, 1,2-O-Isopropylidene-α-D-glucofuranose,
单丙酮葡萄糖,
CAS:253328-56-2
C9H16O6 / 220.22
MFCD00063244

1,2-O-Isopropylidene-a-D-glucofuranose

单丙酮葡萄糖,

1,2-o-Isopropylidene-α-D-glucofuranose is a potent inhibitor of xylan, which is essential for the growth and development of cancer cells. This compound has been shown to inhibit the activity of several kinases involved in cancer cell proliferation, including protein kinase C and acetylcholine kinase. 1,2-o-Isopropylidene-α-D-glucofuranose exhibits anticancer properties and induces apoptosis in human cancer cells. It is an analog of aprepitant, a drug used to prevent chemotherapy-induced nausea and vomiting in cancer patients. This compound may have potential as a therapeutic agent for the treatment of various types of tumors.

CAS Number253328-56-2
Product Name1,2-O-Isopropylidene-alpha-D-glucofuranose
IUPAC Name1-(6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol
Molecular FormulaC₉H₁₆O₆
Molecular Weight220.22
InChIInChI=1S/C9H16O6/c1-9(2)14-7-5(12)6(4(11)3-10)13-8(7)15-9/h4-8,10-12H,3H2,1-2H3
SMILESCC1(OC2C(C(OC2O1)C(CO)O)O)C
Synonyms(5ξ)-1,2-O-(1-Methylethylidene)-α-D-xylo-hexofuranose;

CAS No: 18549-40-1,253328-56-2 Synonyms: Acetone-D-glucoseMonoacetone glucose MAG   MDL No: MFCD00063244 Chemical Formula: C9H16O6 Molecular Weight: 220.22

COA:

Product name 1,2-O-Isopropylidene-α-D-glucofuranose

CAS: 18549-40-1,253328-56-2      M.F.: C9H16O6      M.W.: 220.22

Quantity:100g from1.86 kg                                            Batch No: 20100104

Items

Standards

Results

Appearance

White crystal powder

Complies

Solubility

Soluble in water, insoluble ether

Complies

Identification

IR and TLC

Complies

Melting point

150°C - 160 °C

156 -158

Optical Activity

[α]20/D (C = 1, water)

−11° −13°

-12.3°

Water

Max.0.5%

0.2%

Residue on ignition

Max. 1%

0.1%

Heavy metal

Max. 20ppm

Complies

TLC*

Should be one spot

One spot

Assay

Min. 98%

99.4%

*The stationary phase is sillica gel, the mobile phase is EtOAc and is charcoalled with 15% H2SO4-EtOH.

References:

1. Gramera RE, Park A, Whistler RL, J. Org. Chem. 1963, Vol28, p3230
2. Borsuk K, Frelek J, ?ysek R, Urba?czyk Z, et al., Chirality 2001, Vol13, Issue 9, p533-540

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