6559-91-7, 4'-去甲表鬼臼毒素, 4'-Demethylepipodophyllotoxin, CAS: 6559-91-7

6559-91-7, 4'-去甲表鬼臼毒素,
4'-Demethylepipodophyllotoxin,
CAS: 6559-91-7
C21H20O8 / 400.379
MFCD00189421

4'-去甲表鬼臼毒素,

4'-Demethylepipodophyllotoxin

Demethylepipodophyllotoxin is a naturally occurring compound that has been shown to inhibit the mitochondrial membrane potential, which may lead to cell death. Demethylepipodophyllotoxin also inhibits the production of low-density lipoprotein cholesterol (LDL-C). This drug has been shown to be effective in reducing the size of solid tumours and resistant mutants in a mouse model. Demethylepipodophyllotoxin binds to the DNA template, preventing DNA synthesis and promoting cell death by inhibiting enzymes activities. Demethylepipodophyllotoxin has been shown to have antimicrobial properties against bacteria, fungi and protozoa as well as antitumour effects on cancer cells.

CAS Number	6559-91-7
Product Name	4'-Demethylepipodophyllotoxin
IUPAC Name	(5R-(5alpha,5abeta,8aalpha,9beta))-5,8,8a,9-Tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one
Molecular Formula	C21H20O8
Molecular Weight	400.379 g/mol
InChI	InChI=1S/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19+/m0/s1
InChI Key	YVCVYCSAAZQOJI-JHQYFNNDSA-N
SMILES	O=C1OC[C@]2([H])[C@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(O)C(OC)=C5)[C@]21[H]
Solubility	Soluble in DMSO
Synonyms	4'-demethyl epipodophyllotoxin, 4'-demethylepipodophyllotoxin
Canonical SMILES	COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Isomeric SMILES	COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O

COA:

Product name: 4'-Demethylepipodophyllotoxin CAS: 6559-91-7

M.F.: C₂₁H₂₀O₈ M.W._:400.379 Quantity:3.8kg

*Items*	*Standards*	*Results*
Appearance	White or off-white crystal powder	Complies
Solubility	Soluble in DMF, insoluble in water	Complies
Identification	IR and HPLC	Complies
NMR and MS	Should comply	Should comply
Total impurity	Max. 2%	Complies
Heavy metal	Max. 50ppm	Complies
Residue on ignition	Max. 0.5%	0.01%
TLC	One spot	One spot
Assay by HPLC	Min. 98%	98.2%