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124223-99-0 ,4-Methylumbelliferyl 2-acetamido-2-deoxy-a-D-galactopyranoside,CAS:124223-99-0

GalNAc-a-4MU,ANAGA,
4MU N-acetyl-a-D-galactosaminide,
,4-Methylumbelliferyl 2-acetamido-2-deoxy-a-D-galactopyranoside,
CAS:124223-99-0
C18H21NO8 / 379.36
MFCD00270047

4-Methylumbelliferyl 2-acetamido-2-deoxy-a-D-galactopyranoside

4-甲基伞形酮-2-乙酰氨基-2-脱氧-a-D-半乳糖苷

A fluorogenic substrate for the detection of lysosomal enzyme N-acetyl-α-D-galactopyranosiaminidase (NAGA), which is driving the pathogenesis of Schindler disease. Also substrate for endo-α-N-acetylgalactosaminidase (O-glycosidase), which cleaves O-linked core 1 and core 3 disaccharides from glycoproteins.

4-Methylumbelliferyl 2-acetoamido-2-deoxy-α-D-galactopyranoside (4-MU-2-acetoamido-2-deoxy-α-Gal) is a fluorogenic substrate used to quantify α- and β-galactopyranosaminidase activity. 4-MU-2-acetoamido-2-deoxy-α-Gal is cleaved by α- and β-galactopyranosaminidase to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.

CAS Number124223-99-0
Product Name4-Methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-galactopyranoside
IUPAC NameN-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide
Molecular FormulaC₁₈H₂₁NO₈
Molecular Weight379.36
InChIInChI=1S/C18H21NO8/c1-8-5-14(22)26-12-6-10(3-4-11(8)12)25-18-15(19-9(2)21)17(24)16(23)13(7-20)27-18/h3-6,13,15-18,20,23-24H,7H2,1-2H3,(H,19,21)/t13-,15-,16+,17-,18+/m1/s1
SMILESCC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)NC(=O)C
Synonyms7-[[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one; GalNAc1-α-4MU;
CAS No: 124223-99-0 Synonyms: GalNAc-a-4MUANAGA4MU N-acetyl-a-D-galactosaminide4-Methylumbelliferyl N-acetyl-a-D-galactosaminide MDL No: MFCD00270047 Chemical Formula: C18H21NO8 Molecular Weight: 379.36


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