2616-72-0 , Naphthol AS-TR phosphate

2616-72-0 , Naphthol AS-TR phosphate,
Cas:2616-72-0
C18H15ClNO5P / 391.74
MFCD00042716

Naphthol AS-TR phosphate

萘酚AS-TR磷酸酯,

Naphthol AS-TR phosphate is an experimental drug that inhibits the activity of proteases, which are enzymes that break down proteins. It was shown to have a high specificity for Onchocerca volvulus, a parasite that causes onchocerciasis in humans. Naphthol AS-TR phosphate has been shown to inhibit the expression of target genes in experimental infections with this parasite and has also been used to treat cancer. This drug is cell specific and can be used for histochemical staining by binding to phosphatase enzymes.

NASTRp is an inhibitor of CREB-CBP complex which possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress.

CAS Number	2616-72-0
Product Name	N-(4-Chloro-2-methylphenyl)-3-(phosphonooxy)naphthalene-2-carboxamide
IUPAC Name	[3-[(4-chloro-2-methylphenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
Molecular Formula	C18H15ClNO5P
Molecular Weight	391.7 g/mol
InChI	InChI=1S/C18H15ClNO5P/c1-11-8-14(19)6-7-16(11)20-18(21)15-9-12-4-2-3-5-13(12)10-17(15)25-26(22,23)24/h2-10H,1H3,(H,20,21)(H2,22,23,24)
InChI Key	SHTFMUPUBYXPCD-UHFFFAOYSA-N
SMILES	CC1=C(C=CC(=C1)Cl)NC(=O)C2=CC3=CC=CC=C3C=C2OP(=O)(O)O
Solubility	Soluble in DMSO
Synonyms	naphthol AS-TR phosphate, NASTRp compound
Canonical SMILES	CC1=C(C=CC(=C1)Cl)NC(=O)C2=CC3=CC=CC=C3C=C2OP(=O)(O)O