69227-93-6,DDM,n-Dodecyl-β-D-maltoside , CAS: 69227-93-6

DDM,
Lauryl maltoside,
n-Dodecyl 4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside,
Cas:69227-93-6
C24H46O11 / 510.62
MFCD00043012

Dodecyl b-D-maltopyranoside

十二烷基-b-D-麦芽糖苷

Dodecyl maltoside (DDM) is a non-ionic detergent that consists of a hydrophilic maltose head and a hydrophobic long chain alkyl tail. It has a relatively low critical micelle concentration of 0.17 mM and is considered a gentle but powerful detergent. DDM is often the best tool for solubilising/crystallising membrane proteins. Membrane proteins usually have α-helical structures that are easily destroyed when the protein is released from its membrane environment. DDM can often preserve these structures during the solubilisation. In addition, membrane proteins can often be renatured when isolated with DDM.

n-Dodecyl-β-D-maltoside (DDM) is a non-ionic detergent commonly used to solubilize membrane-associated proteins. In particular, it helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation. The critical micelle concentration of DDM is approximately 0.18 mM in water, decreases in the presence of sodium chloride or sucrose, and increases in urea.

DDM is the most widely used detergent for the isolation and purification of GPCR’s.

Dodecyl beta-D-maltoside is a glycoside resulting from attachment of a dodecyl group to the reducing-end anomeric centre of a beta-maltose molecule. It has a role as a detergent. It is a glycoside and a disaccharide derivative. It derives from a hydride of a beta-maltose.

CAS Number	69227-93-6
Product Name	Dodecyl-beta-D-maltoside
IUPAC Name	(2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-6-dodecoxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
Molecular Formula	C24H46O11
Molecular Weight	510.62 g/mol
InChI	InChI=1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1
InChI Key	NLEBIOOXCVAHBD-QKMCSOCLSA-N
SMILES	CCCCCCCCCCCCOC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)O)O)O)O)O
Solubility	Soluble in DMSO
Synonyms	dodecyl maltoside, dodecyl(-beta-D-)maltoside, dodecyl-beta-D-maltoside, lauryl maltoside, n-dodecyl-beta-D-maltoside
Canonical SMILES	CCCCCCCCCCCCOC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)O)O)O)O)O
Isomeric SMILES	CCCCCCCCCCCCO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O

CAS No: 69227-93-6 Synonyms: DDMLauryl maltosiden-Dodecyl 4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside MDL No: MFCD00043012 Chemical Formula: C24H46O11 Molecular Weight: 510.62

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