Methyl b-D-glucopyranoside hemihydrate

甲基--b-D-吡喃葡萄糖苷

Methyl beta-d-glucopyranoside (MBG) hemihydrate is a carbohydrate molecule commonly used as a research tool in various scientific fields. Among its many uses, it is most commonly utilized to mimic interactions between complex carbohydrates and proteins. In this paper, the focus is on providing a comprehensive review of MBG hemihydrate by delving into its physical and chemical properties, synthesis and characterization, analytical methods, biological properties, toxicity and safety in scientific experiments, applications in scientific experiments, current state of research, potential implications in various fields of research, limitations, and future directions.

Definition and Background:

MBG hemihydrate is a simple carbohydrate molecule that is structurally similar to glucose. It is composed of six carbon atoms, an oxygen atom, and ten hydrogen atoms. MBG hemihydrate is a white powder and is soluble in water. The carbohydrate is commonly used in research studies as an analog of more complex carbohydrates, particularly glycosaminoglycans. Glycosaminoglycans are molecules that are found in various tissues in the human body, including cartilage, tendons, and bones. They play a crucial role in maintaining the structural integrity of tissues and provide an important biological function.

Physical and Chemical Properties:

MBG hemihydrate has several notable physical and chemical properties. It is a white powder that is freely soluble in water but poorly soluble in many organic solvents such as ethanol, methanol, and acetone. The molecular weight of the carbohydrate is 194.18 g/mol. Its melting point is approximately 162℃, and it is a stable compound when stored at room temperature.

Synthesis and Characterization:

The synthesis of MBG hemihydrate involves the hydrolysis of cellulose or starch with a strong acid such as sulfuric acid. The resulting product is then neutralized and crystallized to obtain the final product. Characterization of MBG hemihydrate is typically done through a combination of spectroscopic (infrared, nuclear magnetic resonance) and chromatographic techniques.

Analytical Methods:

MBG hemihydrate can be analyzed using several methods. One common method is high-performance liquid chromatography (HPLC), which allows for the separation and quantification of carbohydrates. Additionally, thin-layer chromatography (TLC) and capillary electrophoresis (CE) can also be employed to separate and analyze MBG hemihydrate.

Biological Properties:

MBG hemihydrate is commonly used in research studies as a mimic of more complex carbohydrates such as glycosaminoglycans. It has been shown to play a role in cellular adhesion and signaling, angiogenesis, and wound healing. Furthermore, studies have demonstrated that MBG hemihydrate can act as an antiviral agent against certain viruses such as hepatitis C virus.

Toxicity and Safety in Scientific Experiments:

MBG hemihydrate has been classified as non-toxic and non-irritant to skin and eyes. It is also not classified as a hazardous substance by regulatory agencies such as the European Chemicals Agency (ECHA). However, precautions should still be taken during handling and inhalation of the powder should be avoided.

Applications in Scientific Experiments:

MBG hemihydrate has several applications in scientific experiments. It is commonly used as a substrate for enzymes that hydrolyze complex carbohydrates. Additionally, it is used as a mimic of more complex carbohydrates in studies of protein-carbohydrate interactions. Its ability to act as an antiviral agent has also garnered interest in its potential use as a treatment for hepatitis C virus.

Current State of Research:

The current state of research on MBG hemihydrate is primarily focused on its applications in the medical field. Specifically, there is interest in its use as a treatment for hepatitis C virus. Additionally, research has been conducted on its potential use in wound healing and as a substrate for enzyme hydrolysis.

Potential Implications in Various Fields of Research and Industry:

The potential implications of MBG hemihydrate in various fields of research and industry are vast. In the medical field, its potential use as a treatment for hepatitis C virus has garnered attention. Additionally, its ability to mimic more complex carbohydrates has applications in drug discovery and the study of protein-ligand interactions. In the cosmetics industry, it could be utilized in the development of moisturizing products. In the food industry, it could be used as a low-calorie sugar substitute.

Limitations and Future Directions:

One limitation of MBG hemihydrate is its limited ability to mimic more complex carbohydrates. Additionally, further research is needed to fully understand its potential toxicity and safety concerns. Future directions in research include the development of novel synthesis methods for MBG hemihydrate, as well as its use in the study of protein-carbohydrate interactions and drug discovery.

Conclusion:

MBG hemihydrate is a simple carbohydrate molecule with several notable physical and chemical properties. Its ability to mimic more complex carbohydrates has led to numerous applications in scientific research. While further research is needed to fully understand its potential uses and limitations, MBG hemihydrate has potential implications in various fields of research and industry.

COA:

Product name: Methyl-beta-D-glucopyranoside hemihydrate             Quantity: 1.7kg

CAS: 7000-27-3, 709-50-2    M.F.: C₇H₁₄ O₆.1/2H₂O     M.W.: 212.2    Batch No: 20130302