4084-27-9 , 3-葡萄糖醛酮, 3-DG,
3-Deoxy-D-glucosone,
CAS:4084-27-9
C6H10O5 / 162.14
MFCD01723101
3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes. It is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies. 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.
3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes.
3-Deoxy-D-glucosone is a compound that belongs to the group of monosaccharides and has a basic structure. It can be found in many types of biological samples, including blood. The x-ray diffraction data for 3-deoxy-D-glucosone shows an asymmetric unit of two molecules with a coordination geometry of 2.3. This compound is known to have high protein oxidation rates, which are caused by dna binding activity. 3-Deoxyglucosone has been shown to be involved in the pathogenic mechanism of many types of cancers.
CAS Number | 4084-27-9 |
Product Name | 3-Deoxyglucosone |
IUPAC Name | (4S,5R)-4,5,6-trihydroxy-2-oxohexanal |
Molecular Formula | C6H10O5 |
Molecular Weight | 162.14 g/mol |
InChI | InChI=1S/C6H10O5/c7-2-4(9)1-5(10)6(11)3-8/h2,5-6,8,10-11H,1,3H2/t5-,6+/m0/s1 |
InChI Key | ZGCHLOWZNKRZSN-NTSWFWBYSA-N |
SMILES | C(C(C(CO)O)O)C(=O)C=O |
Synonyms | 3-Deoxy-D-erythro-hexulose; 2-Keto-3-deoxyglucose; D-3-Deoxyglucosone; 3-Deoxy-D-erythro-hexos-2-ulose; 3DG; 3-Deoxy-D-glucosone; |
Canonical SMILES | C(C(C(CO)O)O)C(=O)C=O |
Isomeric SMILES | C([C@@H]([C@@H](CO)O)O)C(=O)C=O |
CAS No: 4084-27-9 Synonyms: 3-Deoxy-D-erythro-hexulose2-Keto-3-deoxyglucose MDL No: MFCD01723101 Chemical Formula: C6H10O5 Molecular Weight: 162.14 |
References: 1. Kato H, et al., Agric. Biol. Chem. 1987, 51, p6832. Hayase F, et al., J. Biol. Chem. 1989, 264, p3758 |
We can also supply similar following products.
D-Psicose or D-Allulose | CAS: | 551-68-8,23140-52-5 |
D-Fructose | CAS: | 57-48-7 |
a-D-Fructopyranose | CAS: | 10489-81-3 |
b-D-Fructopyranose | CAS: | 7660-25-5 |
a-D-Fructofuranose | CAS: | 10489-79-9 |
b-D-Fructofuranose | CAS: | 470-23-5 |
L-Fructose | CAS: | 7776-48-9 |
L-Sorbose | CAS: | 87-79-6 |
D-Sorbose | CAS: | 3615-56-3 |
D-Xylulose | CAS: | 551-84-8 |
L-Xylulose | CAS: | 527-50-4 |
3-Deoxy-D-glucosone | CAS: | 4084-27-9 |
D-Erythrulose | CAS: | 496-55-9 |
D-Threose | CAS: | 533-50-6 |
1-Deoxy-D-ribulose | CAS: | |
1-Deoxy-D-xylulose | CAS: | 60299-43-6 |
联系人:邢经理
手机: 18310328607 , 13621067991,13552979007
电话:86+10-61274189
邮箱:chemsynlab@163.com, zhangchao@chemsynlab.com
地址: 北京市大兴区金苑路26号1幢4层411室