69-65-8, D-甘露醇 ,
D-Mannitol,
CAS:69-65-8
C6H14O6 / 182.17
MFCD00064287
Title: Mannitol
CAS Registry Number: 69-65-8
Additional Names: D-Mannitol; mannite; manna sugar; cordycepic acid
Trademarks: Manicol; Mannidex; Osmitrol (Baxter); Osmosal; Resectisol (McGaw)
Molecular Formula: C6H14O6
Molecular Weight: 182.17
Percent Composition: C 39.56%, H 7.75%, O 52.70%
Literature References: Widespread in plants and plant exudates; obtained from manna and seaweeds: The Carbohydrates, W. Pigman, Ed. (Academic Press, New York, 1957) pp 249-250. Forms a stable, equimolar compound with H2O2: S. Tanatar, J. Russ. Phys. Chem. Soc. 40, 376, C.A. 3, 883 (1909). Prepd by electrolytic reduction of glucose: Creighton, Can. Chem. Process Ind. 26, 690 (1942), C.A. 37, 10885 (1943); Wolfrom et al., J. Am. Chem. Soc. 68, 578 (1946). Prepn from seaweed: Sorensen, Kristensen, US 2516350 (1950); by hydrogenation of invert sugar, monosaccharides, and sucrose: Kasehagen, and Kasehagen, Luskin, US 2642462, US 2749371, and US 2759024 (1953, 1956, and 1956, all to Atlas Powder). Review of prepn: Pigman, loc. cit. Novel synthesis: M. Makkee et al., Chem. Commun. 1980, 930.
Properties: Orthorhombic needles from alc, mp 166-168°. Sweetish taste. d20 1.52. bp3.5 290-295°. Is inactive or very slightly levorotatory in distilled water. Forms sodium mannitoborate on addition of borax giving a greater rotation: [a]D20 +23° ® +24° after 1 hr in a soln of 10 g mannitol +12.8 g borax + sufficient H2O to make 100 ml. One gram dissolves in ~5.5 ml water, 83 ml alcohol; more sol in hot water. Insol in ether. Sol in pyridine, aniline, aq solns of alkalies. One gram dissolves in 18 ml glycerol (d 1.24). Soly tables: Creighton, Klauder, J. Franklin Inst. 195, 687 (1923). pKa (18°): 13.50.
Melting point: mp 166-168°
Boiling point: bp3.5 290-295°
pKa: pKa (18°): 13.50
Optical Rotation: [a]D20 +23° ® +24° after 1 hr in a soln of 10 g mannitol +12.8 g borax + sufficient H2O to make 100 ml
Density: d20 1.52; d 1.24
Use: Used with boric acid in the manuf of dry electrolytic condensers for radio applications; in making artificial resins and plasticizers; in pharmacy as excipient and diluent for solids and liqs; in analytical chemistry for boron determinations; in the manuf of mannitol hexanitrate. Used in the food industry as anticaking and free-flow agent, flavoring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener.
Therap-Cat: Diuretic. Diagnostic aid (renal function).
Keywords: Diagnostic Aid; Diuretic.
CAS Number | 69-65-8 |
Product Name | Mannitol |
IUPAC Name | (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol |
Molecular Formula | C6H14O6 |
Molecular Weight | 182.17 g/mol |
InChI | InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1 |
InChI Key | FBPFZTCFMRRESA-KVTDHHQDSA-N |
SMILES | C(C(C(C(C(CO)O)O)O)O)O |
Solubility | greater than or equal to 100 mg/mL at 68° F (NTP, 1992) 216000 mg/L (at 25 °C) 1 g in about 5.5 ml water; more sol in hot water; insol in ether; sol in pyridine, aniline; sol in aq soln of alkalies; 1 g dissolves in 18 ml glycerol (density 1.24); 1 g dissolves in about 83 ml alc In water, 2.16X10+5 mg/l @ 25 °C 216 mg/mL at 25 °C |
Synonyms | (L)-Mannitol, Mannitol, Osmitrol, Osmofundin |
Canonical SMILES | C(C(C(C(C(CO)O)O)O)O)O |
Isomeric SMILES | C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O |
Name: D-Mannitol CAS: 69-65-8 M.F.: C6H14O6
M.W.: 182.17 Batch No: 20120403 Quantity:262g
Items | Standards | Results |
Appearance | White crystalline power | Positive |
Solubility | Readily soluble in water and insoluble in ether | Positive |
NMR and MS | Should comply | Complies |
Identification | IR and TLC | Positive |
M.P. | 160℃ ~170℃ | 162℃ ~165℃ |
Loss Weight On Dryness | Max. 1% | Complies |
Heavy Metal | Max. 20ppm | Complies |
TLC (15%H2SO4-C2H5OH) | One spot | Complies |
Assay (HPLC) | Min. 98% | 99.6% |
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