N-Decanoyl-N-methylglucamine

癸酰基-N-甲葡糖酰胺

N-Decanoyl-N-methylglucamine is a fatty acid that is used as a cationic surfactant in detergents and cleaning products. It has been shown to have conformational properties that can be influenced by the acyl chain length. N-Decanoyl-N-methylglucamine has also been shown to bind to antibodies and other proteins, which may lead to antibody response or changes in their conformation. N-Decanoyl-N-methylglucamine binds to receptors on cells, triggering cell lysis and monoclonal antibody production. The optimum pH for this chemical is between 5 and 6, and it has been shown to undergo titration calorimetry at temperatures greater than 100°C.

N-Oxodecyl meglumine (NDM) is a crucial chemical compound that has received increased attention in scientific research over the last few years. This paper aims to provide a comprehensive review of NDM, including its definition, background, physical and chemical properties, synthesis and characterization, analytical methods, biological properties, toxicity and safety in scientific experiments, applications in scientific experiments, current state of research, potential implications in various fields of research and industry, limitations, and future directions.

Definition and Background:

NDM is a chemical compound that is derived from meglumine, which is a stable organic compound that has multiple uses in the pharmaceutical industry. NDM has a similar structure to meglumine; however, it possesses a unique N-oxide group at the end of its aliphatic chain. This unique structure makes NDM more soluble in water than meglumine.

Physical and Chemical Properties:

NDM is a white to off-white crystalline powder that is soluble in water, methanol, and ethanol. It has a molecular weight of 349.47 g/mol and a melting point of 110-120°C. The compound is stable under normal conditions and possesses a poor photostability profile.

Synthesis and Characterization:

NDM can be synthesized by the reaction between meglumine and sodium chlorite in acetic acid under specific reaction conditions. The synthesis reaction yields both NDM and its N-oxide reduction product N-decyl meglumine. Characterization of NDM can be performed using various techniques such as FTIR, 1H-NMR spectroscopy, and mass spectrometry.

Analytical Methods:

Several analytical methods have been developed for the detection and quantification of NDM in different matrices. These methods include high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and liquid chromatography-mass spectrometry (LC-MS).

Biological Properties:

NDM exhibits antimicrobial activity against various bacterial and fungal strains. The compound also possesses antiparasitic properties and has demonstrated efficacy in the treatment of leishmaniasis. Furthermore, NDM has been studied for its anti-cancer activity and has shown potential in the treatment of pancreatic and colon cancers.

Toxicity and Safety in Scientific Experiments:

Pre-clinical studies have shown that NDM is well-tolerated in animals and has a low toxicity profile. However, studies on the toxicity and safety of NDM in humans are limited, and further research is required in this field.

Applications in Scientific Experiments:

NDM has numerous applications in scientific experiments due to its unique properties. It is used as a solubilizer in drug formulations, as a stabilizer in peptides and proteins, and as a reagent in organic chemistry. Additionally, NDM is used as a biocide in personal care products and in the food and beverage industry.

Current State of Research:

Currently, research on NDM is limited to pre-clinical studies, and more extensive clinical trials are required to assess the compound's therapeutic potential fully. Nevertheless, the scientific community has recognized the broad range of potential applications of NDM and has continued to explore the compound's properties.

Potential Implications in Various Fields of Research and Industry:

NDM has significant potential in various fields of research and industry. It has shown promise in drug delivery systems, particularly for hydrophobic drugs. Additionally, NDM has applications in cosmetics, personal care products, and the food and beverage industry.

Limitations and Future Directions:

Although NDM exhibits exceptional properties, it has several limitations. One of the significant limitations of NDM is its high cost of production. Therefore, future research should focus on developing cost-effective synthesis methods. Additionally, although NDM exhibits low toxicity, further research is required to understand its long-term effects on human health. In terms of future directions, it is vital to explore the use of NDM in a wide range of industries, particularly in drug formulation and delivery systems, where the compound shows the most promise. Furthermore, research is needed to investigate NDM's potential as a green biocide in agricultural industries.

Conclusion:

In conclusion, N-Oxodecyl meglumine is a unique chemical compound with various useful properties that have potential applications in scientific research and industry. While research on NDM remains relatively limited, the scientific community recognizes the range of potential applications of the compound, and its use in drug delivery systems, organic chemistry, and biocides shows promise. Moving forward, additional research is required to advance the scientific understanding of NDM and identify new applications for this incredible compound.