维生素C乙基醚, 3-O-Ethyl-L-ascorbic Acid

3-o-ethyl-l-ascorbic acid  is a fruit extract that can be used for the treatment of leukoderma and Chinese herbal medicine. It has been shown to inhibit carcinogenesis in vitro. The molecule can bind to glycerin, collagen and hydroxyl group on the surface of cells, which inhibits cell proliferation. This compound also exhibits antiinflammatory effects as it binds to erythrocyte membrane protein and blocks the uptake of hydrogen peroxide by erythrocytes.

CAS No: 86404-04-8

MDL No: MFCD09261382

Chemical Formula: C8H12O6

Molecular Weight: 204.18 

Smiles: CCOC1=C(C(=O)O[C@@H]1[C@H](CO)O)O

Melting Point:114 °C

Storage: store at 2°C - 8°C, close container well

3-O-乙基抗坏血酸醚又叫维生素C乙基醚。维生素C由于其结构上有4个羟基，不能被皮肤直接吸收，且容易被氧化而导致变色，作为美白剂在化妆品使用上受到了限制。3位羟基烃基化后Chemicalbook制得的维生素C乙基醚是不变色的维生素C衍生物，而且不影响其生物活性的作用，从而填补了市场同类产品空白。研究表明，维生素C乙基醚进入皮肤后容易被酶分解而发挥维生素C的作用。

(R)-5-((S)-1,2-Dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one is a fruit extract that can be used for the treatment of leukoderma and Chinese herbal medicine. It has been shown to inhibit carcinogenesis in vitro. The molecule can bind to glycerin, collagen and hydroxyl group on the surface of cells, which inhibits cell proliferation. This compound also exhibits antiinflammatory effects as it binds to erythrocyte membrane protein and blocks the uptake of hydrogen peroxide by erythrocytes.

3-O-Ethyl-L-ascorbic acid is a stable derivative of vitamin C that has gained widespread attention due to its unique properties, including high stability, increased bioavailability, and potential applications in various fields of research and industry. The purpose of this paper is to provide a comprehensive overview of 3-O-Ethyl-L-ascorbic acid, including its definition, background, physical and chemical properties, synthesis and characterization, analytical methods, biological properties, toxicity and safety in scientific experiments, applications in scientific experiments, current state of research, potential implications in various fields of research and industry, limitations, and future directions.

Definition and Background:

Vitamin C, also known as L-ascorbic acid, is an essential nutrient that plays a vital role in human health. However, due to its instability and sensitivity to environmental factors, such as heat, light, and pH, vitamin C is challenging to incorporate into skincare and food products. Therefore, researchers have been exploring stable derivatives of vitamin C, such as 3-O-Ethyl-L-ascorbic acid, which can retain the beneficial properties of vitamin C while overcoming its limitations.

Physical and Chemical Properties:

3-O-Ethyl-L-ascorbic acid is a white powder with a molecular formula of C8H12O6. It has a molecular weight of 204.18 g/mol and a melting point of 112-116°C. The compound is soluble in water, ethanol, and propylene glycol and has a neutral pH.

Synthesis and Characterization:

3-O-Ethyl-L-ascorbic acid is synthesized by reacting L-ascorbic acid with ethanol under acidic conditions. The reaction results in the formation of 3-O-Ethyl-L-ascorbic acid, which is then purified and characterized using various analytical techniques, including nuclear magnetic resonance (NMR) spectroscopy, high-performance liquid chromatography (HPLC), and mass spectrometry (MS).

Analytical Methods:

Several analytical methods are used to evaluate the purity, stability, and quality of 3-O-Ethyl-L-ascorbic acid, including HPLC, UV-visible spectroscopy, and capillary electrophoresis (CE).

Biological Properties:

3-O-Ethyl-L-ascorbic acid has been shown to exhibit antioxidant, anti-inflammatory, and skin-lightening properties. The compound can penetrate the skin more efficiently than L-ascorbic acid, making it a promising ingredient in skincare products.

Toxicity and Safety in Scientific Experiments:

Several studies have demonstrated that 3-O-Ethyl-L-ascorbic acid is non-toxic and safe for use in scientific experiments. However, further studies are needed to determine the long-term effects of the compound.

Applications in Scientific Experiments:

3-O-Ethyl-L-ascorbic acid has potential applications in several fields of research, including skincare, pharmaceuticals, and food science. The compound can be used as an ingredient in topical skincare products, as a food preservative, and as a potential treatment for various diseases, including cancer and diabetes.

Current State of Research:

The current state of research on 3-O-Ethyl-L-ascorbic acid is focused on identifying new applications for the compound, improving its stability, and optimizing its synthesis and characterization.

Potential Implications in Various Fields of Research and Industry:

3-O-Ethyl-L-ascorbic acid has potential implications in various fields of research and industry, including skincare, pharmaceuticals, and food science. The compound has been shown to exhibit promising properties that can be used to develop new products and treatments.

Limitations:

One limitation of 3-O-Ethyl-L-ascorbic acid is its high cost compared to other vitamin C derivatives. Additionally, further studies are needed to determine the long-term safety and efficacy of the compound in various applications.

Future Directions:

Future directions for the research on 3-O-Ethyl-L-ascorbic acid include:

1. Exploring new applications for the compound in skincare and food science.

2. Developing more affordable and scalable methods for synthesizing 3-O-Ethyl-L-ascorbic acid.

3. Improving the stability and shelf life of the compound.

4. Evaluating the long-term safety and efficacy of the compound in various applications.

5. Investigating the potential synergistic effects of 3-O-Ethyl-L-ascorbic acid when combined with other compounds.

6. Exploring the effects of 3-O-Ethyl-L-ascorbic acid on the gut microbiome.

7. Developing new methods for delivering 3-O-Ethyl-L-ascorbic acid to targeted tissues and organs.

8. Exploring the use of 3-O-Ethyl-L-ascorbic acid as a potential treatment for neurodegenerative diseases.

9. Investigating the potential use of 3-O-Ethyl-L-ascorbic acid as a biomarker for disease diagnosis.

10. Exploring the potential use of 3-O-Ethyl-L-ascorbic acid in gene editing and gene therapy.