103213-40-7 , Glutaryl-Gly-Arg-AMC.HCl; Glutaryl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride

103213-40-7 , Glutaryl-Gly-Arg-AMC.HCl;
Glutaryl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride
C23H31ClN6O7 / 538.98
MFCD00058182

Glutaryl-Gly-Arg-AMC.HCl

Glutaryl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride

Glutaryl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride is a potent elastase inhibitor. It has been shown to inhibit the proteolytic activity of elastases and serine proteinases, which are responsible for lysosomal degradation. This drug has also been shown to have strong anti-infective properties against tropical diseases such as leishmaniasis, malaria, and schistosomiasis. Glutaryl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride is also effective against human skin diseases such as psoriasis and atopic dermatitis. The mechanism of action of this drug may be due to its ability to inhibit the production of metalloproteinases that degrade collagen in the extracellular matrix (ECM), leading to a reduction in ECM degradation and an increase in ECM synthesis.

CAS Number	103213-40-7
Product Name	5-[[2-[[5-(Diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid;hydrochloride
IUPAC Name	5-[[2-[[5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid;hydrochloride
Molecular Formula	C23H31ClN6O7
Molecular Weight	539 g/mol
InChI	InChI=1S/C23H30N6O7.ClH/c1-13-10-21(34)36-17-11-14(7-8-15(13)17)28-22(35)16(4-3-9-26-23(24)25)29-19(31)12-27-18(30)5-2-6-20(32)33;/h7-8,10-11,16H,2-6,9,12H2,1H3,(H,27,30)(H,28,35)(H,29,31)(H,32,33)(H4,24,25,26);1H
InChI Key	JSJHBZGTMAWMAP-UHFFFAOYSA-N
SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCCN=C(N)N)NC(=O)CNC(=O)CCCC(=O)O.Cl
Canonical SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCCN=C(N)N)NC(=O)CNC(=O)CCCC(=O)O.Cl