145514-04-1, Amdoxovir, CAS:145514-04-1

145514-04-1, Amdoxovir,
CAS:145514-04-1
C9H12N6O3 / 252.23

氨多索韦, Amdoxovir

A reverse transcriptase inhibitor potentially for the treatment of HIV infection. In vitro studies have shown that amdoxovir may be an effective option for treating people for whom the NRTIs(nucleoside reverse transcriptase inhibitors) lamivudine, emtricitabine, zidovudine, and stavudine are not working. In one such study, Amdoxovir was shown to act synergistically with zidovudine in vitro and the combination prevents or delays the selection of thymidine analogue and K65R mutations.

CAS Number	145514-04-1
Product Name	Amdoxovir
IUPAC Name	[(2R,4R)-4-(2,6-diaminopurin-9-yl)-1,3-dioxolan-2-yl]methanol
Molecular Formula	C9H12N6O3
Molecular Weight	252.23 g/mol
InChI	InChI=1S/C9H12N6O3/c10-7-6-8(14-9(11)13-7)15(3-12-6)4-2-17-5(1-16)18-4/h3-5,16H,1-2H2,(H4,10,11,13,14)/t4-,5-/m1/s1
InChI Key	RLAHNGKRJJEIJL-RFZPGFLSSA-N
SMILES	C1C(OC(O1)CO)N2C=NC3=C(N=C(N=C32)N)N
Solubility	Soluble in DMSO
Synonyms	2,6-diaminopurine dioxolane, 4-(2,6-diamino-9H-purin-9-yl)-1,3,-dioxolane-2-methanol, amdoxovir
Canonical SMILES	C1C(OC(O1)CO)N2C=NC3=C(N=C(N=C32)N)N
Isomeric SMILES	C1[C@@H](O[C@@H](O1)CO)N2C=NC3=C(N=C(N=C32)N)N