460085-45-4 , 4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt

460085-45-4 , 4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt;
4-Methylumbelliferyl N-sulpho-a-D-glucosaminide.Na; 4-MU-GlcNS; M3A; 4MU-a-N-sulpho-D-glucosaminide,
Cas:460085-45-4
C16H18NO10SNa / 439.37
MFCD02683374

4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt

4-Methylumbelliferyl N-sulpho-a-D-glucosaminide.Na; 4-MU-GlcNS; M3A; 4MU-a-N-sulpho-D-glucosaminide

A substrate used for the diagnosis of Sanfilippo disease type A (MPS IIIA).

4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.

CAS Number	460085-45-4
Product Name	4-Methylumbelliferyl 2-deoxy-2-sulfamino-alpha-D-glucopyranoside sodium salt
IUPAC Name	sodium;N-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]sulfamate
Molecular Formula	C₁₆H₁₈NNaO₁₀S
Molecular Weight	439.37
InChI	InChI=1S/C16H19NO10S.Na/c1-7-4-12(19)26-10-5-8(2-3-9(7)10)25-16-13(17-28(22,23)24)15(21)14(20)11(6-18)27-16;/h2-5,11,13-18,20-21H,6H2,1H3,(H,22,23,24);/q;+1/p-1/t11-,13-,14-,15-,16+;/m1./s1
SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)NS(=O)(=O)[O-].[Na+]
Synonyms	7-[[2-Deoxy-2-(sulfoamino)-α-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one Sodium Salt;