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85618-21-9, OG, Octyl-β-D-thioglucopyranoside, CAS:85618-21-9

85618-21-9,OG,Octyl-β-D-thioglucopyranoside,
CAS:85618-21-9
C14H28O5S / 308.43
MFCD00012189

Octyl b-D-thioglucopyranoside

辛基-beta-D-硫代吡喃葡萄糖苷

Octyl beta-D-thioglucopyranoside is an alkylglycoside non-ionic detergent used for cell lysis and membrane protein isolation. As it is uncharged, it is unlikely to cause protein denaturation or refolding issues, allowing for the isolation of intact macromolecular complexes without affecting protein-protein interactions. Octyl ?-D-thioglucopyranoside is also known as n-Octyl b-D-thioglucoside or OTG and has an aggregation number of 189. It is dialyzable from membrane protein preparations and has a Critical Micelle Concentration (CMC) of 9mM. Octyl ?-D-thioglucopyranoside has similar uses and properties to that of another frequently used surfactant, n-Octyl-beta-D-glucopyranoside. However, Octyl ?-D-thioglucopyranoside is more stable and is unaffected by beta-glucosidase enzyme due to its thioether linkage.

N-Octyl-β-D-thioglucopyranoside (OTG) is a low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization. It has a critical micelle concentration of 7.9-9.0 mM. OTG is stable in aqueous solutions, resistant to degradation by β-glucosidases, and easily removed by dialysis.

CAS Number85618-21-9
Product Name2-Hydroxymethyl-6-octylsulfanyl-tetrahydro-pyran-3,4,5-triol
IUPAC Name(2R,3S,4S,5R)-2-(hydroxymethyl)-6-octylsulfanyloxane-3,4,5-triol
Molecular FormulaC14H28O5S
Molecular Weight308.43 g/mol
InChIInChI=1S/C14H28O5S/c1-2-3-4-5-6-7-8-20-14-13(18)12(17)11(16)10(9-15)19-14/h10-18H,2-9H2,1H3/t10-,11-,12+,13-,14?/m1/s1
InChI KeyCGVLVOOFCGWBCS-RGDJUOJXSA-N
SMILESCCCCCCCCSC1C(C(C(C(O1)CO)O)O)O
SynonymsGlc-S-C7-Me, n-octyl-beta-D-thioglucopyranoside, n-octyl-beta-D-thioglucoside, octyl beta-D-thioglucoside, octyl-thioglucoside, octylthioglucoside
Canonical SMILESCCCCCCCCSC1C(C(C(C(O1)CO)O)O)O
Isomeric SMILESCCCCCCCCS[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O


CAS No: 85618-21-9 Synonyms: n-Octyl b-D-thioglucosideOTG MDL No: MFCD00012189 Chemical Formula: C14H28O5S Molecular Weight: 308.43In Stock.现货

COA:

Product namen-Octyl-β-D-thioglucopyranoside          CAS: 85618-21-9

M.F.C14H28O5S        M.W.: 308.43

Items

Standards

Results

Appearance

White powder

Complies

Solubility

Clear to very slightly hazy colorless to faint yellow solution

Complies

MS and NMR

Should comply

Comply

Identification

IR and TLC

Comply

Loss weight on dryness

Max. 0.5%

0.2%

Residue on ignition

Max. 0.5%

0.1%

Purity by TLC

Min. 98%

Complies

Assay (HPLC)

Min. 98%

99.4%


References:

1. Saito S, Tsuchiya T, Biochem. J. 1984, 222, 829-832
2. Wenk MR, Seelig J, Biophys. J. 1997, 73, 2565-2574

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